Histological Studies on the Possible Protective Effect of Ginger Extract Against Gasoline Exposure Induced Liver Toxicity in Adult Male Albino Rats
- Heba Nageh Gad ELHak
- Mahmoud Ezzat Mohallal
- Nour EL-Din Hussein Saleh
- Hend Maarof Tag
- Mohamed Salah EL-Deen Mahmoud EL-Naggar
leaded gasoline, ginger, liver, histology
Ginger (Zingiber officinale) is used traditionally for many therapeutic purposes. The aim of this study was to
investigate the possible hepatoprotective role of ginger against leaded gasoline induced hepatotoxicity in rats. Sixty male
adult albino rats (120-150 gm) were divided into 10 groups (n=6). Control group. Groups (2-5) inhaled leaded gasoline
with nominal concentration 18.18 ppm for exposure times 3, 6, 9 and 12 hrs/days for 14 successive days. Group (6) orally
received 100 mg/kg ginger per day for 14 days. Group (7-10) inhaled gasoline in same conditions and same exposure times
of groups (2-5), in addition to orally receiving 100 mg/kg ginger during exposure for 14 days. After sacrificing, the liver of
the rats was taken for histological preparation. The results of the present study on the liver showed that subchronic
exposure to gasoline produced changes in some hepatocytes mainly hydrobic degeneration, necrosis and occasional fatty
change were seen, congestion of the central vein and infiltrations of the inflammatory cells in the portal area. It can be
concluded that Ginger administration (100 mg/kg) showed mild hepatoprotective action against gasoline-induced
histological liver damage in rats.
Heba Nageh Gad ELHak, Mahmoud Ezzat Mohallal, Nour EL-Din Hussein Saleh, Hend Maarof Tag, Mohamed Salah EL-Deen Mahmoud EL-Naggar. "Histological Studies on the Possible Protective Effect of Ginger Extract Against Gasoline Exposure Induced Liver Toxicity in Adult Male Albino Rats".INTERNATIONAL JOURNAL OF ENGINEERING DEVELOPMENT AND RESEARCH ISSN:2321-9939, Vol.2, Issue 4, pp.3359-3364, URL :https://rjwave.org/ijedr/papers/IJEDR1404001.pdf
Volume 2 Issue 4
Pages. 3359-3364
